Integrated analysis of the relation to tumor immune microenvironment and predicted value of Stonin1 gene for immune checkpoint blockage and targeted treatment in kidney renal clear cell carcinoma

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Integrated analysis of the relation to tumor immune microenvironment and predicted value of Stonin1 gene for immune checkpoint blockage and targeted treatment in kidney renal clear cell carcinoma

Summary of the Study

  • This study aimed to investigate the role of Stonin1 in the tumor immune microenvironment of kidney renal clear cell carcinoma (KCRCC).
  • The authors used bioinformatics analysis to identify the potential target genes of Stonin1 in KCRCC.
  • The authors also used immunohistochemistry to analyze the expression of Stonin1 in KCRCC tissues.
  • The authors found that Stonin1 was significantly upregulated in KCRCC tissues compared to normal tissues.
  • The authors also found that Stonin1 was associated with the infiltration of CD8+ T cells, macrophages, and neutrophils in KCRCC tissues.
  • The authors concluded that Stonin1 may be a potential target for immune checkpoint blockage and targeted treatment in KCRCC.

Detailed Analysis of the Study

Kidney renal clear cell carcinoma (KCRCC) is one of the most common types of kidney cancer. Despite advances in treatment, the prognosis of KCRCC remains poor. Therefore, it is important to identify novel therapeutic targets for KCRCC. In this study, the authors aimed to investigate the role of Stonin1 in the tumor immune microenvironment of KCRCC.

The authors used bioinformatics analysis to identify the potential target genes of Stonin1 in KCRCC. They found that Stonin1 was significantly upregulated in KCRCC tissues compared to normal tissues. The authors also used immunohistochemistry to analyze the expression of Stonin1 in KCRCC tissues. They found that Stonin1 was associated with the infiltration of CD8+ T cells, macrophages, and neutrophils in KCRCC tissues.

Based on their findings, the authors concluded that Stonin1 may be a potential target for immune checkpoint blockage and targeted treatment in KCRCC. They suggested that further studies are needed to confirm the role of Stonin1 in KCRCC and to explore its potential as a therapeutic target.

  • B!