Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

Summary of the Article

• Alcoholic hepatitis (AH) is a severe form of alcoholic liver disease (ALD) that is characterized by inflammation and necrosis of the liver.
• Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a key role in the regulation of hepatic gene expression.
• In this study, the authors investigated the role of HNF4α in the pathogenesis of AH.
• They found that HNF4α expression was significantly decreased in AH patients compared to healthy controls.
• They also found that HNF4α-dependent gene expression was significantly decreased in AH patients.
• The authors concluded that defective HNF4α-dependent gene expression is a driver of hepatocellular failure in AH.

Detailed Summary of the Article

Alcoholic hepatitis (AH) is a severe form of alcoholic liver disease (ALD) that is characterized by inflammation and necrosis of the liver. It is a major cause of morbidity and mortality in patients with ALD, and is associated with a high risk of mortality. Despite its clinical importance, the molecular mechanisms underlying the pathogenesis of AH remain poorly understood.

Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a key role in the regulation of hepatic gene expression. It is involved in the regulation of a wide range of genes involved in liver metabolism, including those involved in fatty acid and glucose metabolism, as well as those involved in inflammation and fibrosis. In this study, the authors investigated the role of HNF4α in the pathogenesis of AH.

The authors analyzed the expression of HNF4α in liver tissue samples from AH patients and healthy controls. They found that HNF4α expression was significantly decreased in AH patients compared to healthy controls. They also found that HNF4α-dependent gene expression was significantly decreased in AH patients.

The authors concluded that defective HNF4α-dependent gene expression is a driver of hepatocellular failure in AH. They suggest that restoring HNF4α-dependent gene expression may be a potential therapeutic strategy for AH.

Conclusion

In conclusion, this study provides evidence that defective HNF4α-dependent gene expression is a driver of hepatocellular failure in AH. The findings of this study suggest that restoring HNF4α-dependent gene expression may be a potential therapeutic strategy for AH.

source of this article

published: 2023;
Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

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