Correction: Li et al. Immunogenicity of Recombinant-Deficient Lactobacillus casei with Complementary Plasmid Expressing Alanine Racemase Gene and Core Neutralizing Epitope Antigen against Porcine Epidemic Diarrhea Virus. Vaccines 2021, 9, 1084
Summary with Bullet Points
- Li et al. conducted a study to evaluate the immunogenicity of recombinant-deficient Lactobacillus casei (L. casei) with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen against porcine epidemic diarrhea virus (PEDV).
- The study was conducted using a mouse model and the results showed that the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen induced a strong immune response against PEDV.
- The results also showed that the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen was able to induce a strong humoral immune response, as well as a strong cellular immune response.
- The study concluded that the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen is a promising vaccine candidate for the prevention of PEDV infection.
Detailed Summary
Li et al. conducted a study to evaluate the immunogenicity of recombinant-deficient Lactobacillus casei (L. casei) with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen against porcine epidemic diarrhea virus (PEDV). The study was conducted using a mouse model and the results showed that the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen induced a strong immune response against PEDV.
The study found that the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen was able to induce a strong humoral immune response, as well as a strong cellular immune response. The humoral immune response was characterized by the production of high levels of IgG antibodies against PEDV. The cellular immune response was characterized by the production of high levels of IFN-γ and IL-4 cytokines.
The study also found that the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen was able to induce a strong protective immune response against PEDV. The protective immune response was characterized by the production of high levels of neutralizing antibodies against PEDV.
Based on the results of the study, the authors concluded that the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen is a promising vaccine candidate for the prevention of PEDV infection. The authors also suggested that further studies should be conducted to evaluate the safety and efficacy of the recombinant-deficient L. casei with complementary plasmid expressing alanine racemase gene and core neutralizing epitope antigen in animal models.
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