Summary of Li et al. Immunogenicity of Recombinant-Deficient Lactobacillus casei with Complementary Plasmid Expressing Alanine Racemase Gene and Core Neutralizing Epitope Antigen against Porcine Epidemic Diarrhea Virus. Vaccines 2021, 9, 1084
- Li et al. conducted a study to evaluate the immunogenicity of recombinant-deficient Lactobacillus casei (L. casei) expressing alanine racemase gene and core neutralizing epitope antigen against porcine epidemic diarrhea virus (PEDV).
- The study was conducted using a mouse model and the results showed that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen induced a strong immune response against PEDV.
- The results also showed that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen was able to induce a strong humoral immune response, as well as a strong cellular immune response.
- The study concluded that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen is a promising vaccine candidate for the prevention of PEDV infection.
Detailed Summary of Li et al. Immunogenicity of Recombinant-Deficient Lactobacillus casei with Complementary Plasmid Expressing Alanine Racemase Gene and Core Neutralizing Epitope Antigen against Porcine Epidemic Diarrhea Virus. Vaccines 2021, 9, 1084
Li et al. conducted a study to evaluate the immunogenicity of recombinant-deficient Lactobacillus casei (L. casei) expressing alanine racemase gene and core neutralizing epitope antigen against porcine epidemic diarrhea virus (PEDV). The study was conducted using a mouse model and the results showed that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen induced a strong immune response against PEDV. The results also showed that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen was able to induce a strong humoral immune response, as well as a strong cellular immune response.
The study used a mouse model to evaluate the immunogenicity of the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen. The mice were immunized with the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen and the results showed that the immunization induced a strong immune response against PEDV. The results showed that the immunization induced a strong humoral immune response, as measured by the production of anti-PEDV antibodies. The results also showed that the immunization induced a strong cellular immune response, as measured by the production of IFN-γ and IL-4 cytokines.
The study concluded that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen is a promising vaccine candidate for the prevention of PEDV infection. The study showed that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen was able to induce a strong humoral and cellular immune response against PEDV. The results of the study suggest that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen could be used as a vaccine candidate for the prevention of PEDV infection.
Conclusion
Li et al. conducted a study to evaluate the immunogenicity of recombinant-deficient Lactobacillus casei (L. casei) expressing alanine racemase gene and core neutralizing epitope antigen against porcine epidemic diarrhea virus (PEDV). The study used a mouse model to evaluate the immunogenicity of the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen and the results showed that the immunization induced a strong humoral and cellular immune response against PEDV. The study concluded that the recombinant-deficient L. casei expressing alanine racemase gene and core neutralizing epitope antigen is a promising vaccine candidate for the prevention of PEDV infection.
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