Weighted gene co-expression network-based identification of genetic effect of mRNA vaccination and previous infection on SARS-CoV-2 infection

Summary of the Study

• This study aimed to identify the genetic effects of mRNA vaccination and previous infection on SARS-CoV-2 infection.
• The authors used a weighted gene co-expression network analysis (WGCNA) to identify gene modules associated with mRNA vaccination and previous infection.
• The authors identified two gene modules associated with mRNA vaccination and previous infection.
• The authors found that the mRNA vaccination-associated gene module was enriched for genes involved in immune response and inflammation.
• The authors also found that the previous infection-associated gene module was enriched for genes involved in cell cycle and DNA replication.
• The authors concluded that mRNA vaccination and previous infection have distinct genetic effects on SARS-CoV-2 infection.

Detailed Overview of the Study

This study aimed to identify the genetic effects of mRNA vaccination and previous infection on SARS-CoV-2 infection. To do this, the authors used a weighted gene co-expression network analysis (WGCNA) to identify gene modules associated with mRNA vaccination and previous infection. The authors used data from the 1000 Genomes Project to identify gene modules associated with mRNA vaccination and previous infection.

The authors identified two gene modules associated with mRNA vaccination and previous infection. The mRNA vaccination-associated gene module was enriched for genes involved in immune response and inflammation. The previous infection-associated gene module was enriched for genes involved in cell cycle and DNA replication.

The authors concluded that mRNA vaccination and previous infection have distinct genetic effects on SARS-CoV-2 infection. The authors suggest that further research is needed to understand the mechanisms underlying the genetic effects of mRNA vaccination and previous infection on SARS-CoV-2 infection.

source of this article

published: 2023 Mar;
Weighted gene co-expression network-based identification of genetic effect of mRNA vaccination and previous infection on SARS-CoV-2 infection

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