Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing

Motion Lubrication Suppressed Mechanical Activation via Hydrated Fibrous Gene Patch for Tendon Healing

Summary of the Study

• This study aimed to investigate the effects of motion lubrication suppressed mechanical activation (MLSMA) on tendon healing.
• The study used a hydrated fibrous gene patch (HFGP) to deliver genes to the tendon.
• The results showed that MLSMA with HFGP improved the healing of the tendon.
• The study concluded that MLSMA with HFGP is a promising approach for tendon healing.

Detailed Summary of the Study

This study aimed to investigate the effects of motion lubrication suppressed mechanical activation (MLSMA) on tendon healing. The study used a hydrated fibrous gene patch (HFGP) to deliver genes to the tendon. The HFGP was composed of a hydrated fibrous scaffold and a gene-loaded hydrogel. The hydrated fibrous scaffold was made of poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG). The gene-loaded hydrogel was composed of poly(ethylene glycol) diacrylate (PEGDA) and a gene-loaded poly(ethylene glycol) (PEG).

The study used a rat model to investigate the effects of MLSMA with HFGP on tendon healing. The rats were divided into three groups: a control group, a MLSMA group, and a MLSMA with HFGP group. The rats in the MLSMA group were subjected to MLSMA, while the rats in the MLSMA with HFGP group were subjected to MLSMA and HFGP. The results showed that MLSMA with HFGP improved the healing of the tendon.

The study concluded that MLSMA with HFGP is a promising approach for tendon healing. The results showed that MLSMA with HFGP improved the healing of the tendon, suggesting that MLSMA with HFGP could be used to improve the healing of tendons. Furthermore, the study showed that MLSMA with HFGP could be used to deliver genes to the tendon, which could be used to improve the healing of the tendon. Therefore, MLSMA with HFGP could be used to improve the healing of tendons.

source of this article

published: 2023 Feb;
Motion lubrication suppressed mechanical activation via hydrated fibrous gene patch for tendon healing

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