Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models

Summary of Convergent Abnormalities in Striatal Gene Networks in Human Cocaine Use Disorder and Mouse Cocaine Administration Models

• This study aimed to identify convergent abnormalities in striatal gene networks in human cocaine use disorder (CUD) and mouse cocaine administration models.
• The authors used gene expression data from postmortem human striatum and mouse striatum after cocaine administration.
• They identified a set of genes that were differentially expressed in both human CUD and mouse cocaine administration models.
• They also identified a set of genes that were differentially expressed in both human CUD and mouse cocaine administration models.
• The authors then used gene set enrichment analysis to identify pathways and gene networks that were significantly enriched in both human CUD and mouse cocaine administration models.
• The authors found that pathways related to synaptic plasticity, neuronal development, and cell adhesion were significantly enriched in both human CUD and mouse cocaine administration models.
• The authors also identified a set of genes that were differentially expressed in both human CUD and mouse cocaine administration models.
• The authors concluded that there are convergent abnormalities in striatal gene networks in human CUD and mouse cocaine administration models.

Detailed Analysis of Convergent Abnormalities in Striatal Gene Networks in Human Cocaine Use Disorder and Mouse Cocaine Administration Models

This study aimed to identify convergent abnormalities in striatal gene networks in human cocaine use disorder (CUD) and mouse cocaine administration models. To do this, the authors used gene expression data from postmortem human striatum and mouse striatum after cocaine administration. They identified a set of genes that were differentially expressed in both human CUD and mouse cocaine administration models. They then used gene set enrichment analysis to identify pathways and gene networks that were significantly enriched in both human CUD and mouse cocaine administration models.

The authors found that pathways related to synaptic plasticity, neuronal development, and cell adhesion were significantly enriched in both human CUD and mouse cocaine administration models. They also identified a set of genes that were differentially expressed in both human CUD and mouse cocaine administration models. These genes were involved in pathways related to synaptic plasticity, neuronal development, and cell adhesion.

The authors concluded that there are convergent abnormalities in striatal gene networks in human CUD and mouse cocaine administration models. These abnormalities may be related to the development of cocaine use disorder and the effects of cocaine on the brain. Further research is needed to better understand the mechanisms underlying these convergent abnormalities and their implications for the development and treatment of cocaine use disorder.

source of this article

published: 2023 Feb;
Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models

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