Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells

Summary of Key Points

• This study aimed to identify and characterize human gonadotrophic pituitary adenoma stem cells (GPA-SCs).
• GPA-SCs were isolated from human pituitary adenomas and characterized by flow cytometry.
• Gene expression profiling of GPA-SCs was performed using RNA-seq.
• The results showed that GPA-SCs expressed stem cell markers and had a distinct gene expression profile.
• The findings of this study provide new insights into the biology of GPA-SCs and may lead to new therapeutic strategies for pituitary adenomas.

Introduction

Pituitary adenomas are benign tumors of the pituitary gland that can cause a variety of symptoms, including headaches, visual disturbances, and hormonal imbalances. Despite advances in diagnosis and treatment, pituitary adenomas remain a major health problem. The development of new therapeutic strategies for pituitary adenomas is hampered by a lack of understanding of the biology of these tumors.

Recent studies have identified a population of stem cells in pituitary adenomas, termed gonadotrophic pituitary adenoma stem cells (GPA-SCs). GPA-SCs are thought to be responsible for the growth and recurrence of pituitary adenomas. However, the molecular characteristics of GPA-SCs remain largely unknown.

Methods

In this study, the authors aimed to identify and characterize GPA-SCs. GPA-SCs were isolated from human pituitary adenomas and characterized by flow cytometry. Gene expression profiling of GPA-SCs was performed using RNA-seq.

Results

The results showed that GPA-SCs expressed stem cell markers and had a distinct gene expression profile. The authors identified several genes that were differentially expressed in GPA-SCs compared to normal pituitary cells.

Conclusion

The findings of this study provide new insights into the biology of GPA-SCs and may lead to new therapeutic strategies for pituitary adenomas. Further studies are needed to better understand the role of GPA-SCs in the development and progression of pituitary adenomas.

source of this article

published: 2023;
Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells

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